Updated: Nov 14, 2022
Nicotinamide adenine dinucleotide (NAD) is a molecule of great importance for the metabolism of all known life forms. It is required for energy production, the building and breakdown of tissues, healthy aging, detoxification, and multiple other life processes. Reactions involving oxidation and reduction (movement of electrons) often depend on this vital molecule. As such, NAD exists in a balance between an NAD+ (oxidized) and NADH (reduced) state.
Benefits of NAD
- More energy
- Healthy mitochondria (the energy production centers of cells)
- Anti-aging (repairs damaged DNA)
- Mental clarity
- Post-COVID19 symptom improvement
- Reduced inflammation
- Immune system health
- Relief from addictions (helps break bad habits)
Side Effects of an NAD+ Infusion
Because NAD+ is such an important molecule, it can be very activating to the body’s tissues. The areas of the body that produce the most energy during rest, experience the most side effects (brain, heart, gastrointestinal tract).
- Chest pain or discomfort
- Abdominal pain or discomfort
- Nausea and vomiting
- Fluid overload (from IV fluid component)
Most side effects improve immediately after the infusion is stopped. Slowing the rate of infusion can minimize side effects considerably. An NAD+ infusion can be very uncomfortable.
Dosing NAD+ Intravenously
Wonder Medicine gives NAD+ usually as part of a Myers cocktail containing vitamin C, zinc, B vitamins, and magnesium. It is available in 250, 500, and 750 mg doses. We recommend starting at the lowest possible dose and increasing from there.
How Often Should I Receive Treatment
This depends. For treatment of disease, we recommend completing 4 to 8 treatments over 1 to 2 weeks followed by maintenance treatments every 2 to 4 weeks. For general health and anti-aging, treatments every 2 to 4 weeks are generally utilized. More research is needed to better define treatment schedules. IV NAD+ treatments can be combined with other methods of increasing NAD+ to achieve the best results.
Other Ways to Increase NAD+
NAD+ is not absorbed well orally. Rectal suppositories do exist and may be utilized at home. However, some other molecules can be taken orally and have been shown to increase levels of NAD+. Other ways to increase NAD also exist. Exercise is the best method we know of for increasing NAD+ naturally and it has numerous other health benefits!
- Exercise, fasting, heat exposure (saunas)
- Niacin (Vitamin B3) rich foods
- Nicotinamide riboside (NR) supplements
- Nicotinamide mononucleotide (NMN) supplements
- Rajman L, Chwalek K, Sinclair DA. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metab. 2018;27(3):529-547. doi:10.1016/j.cmet.2018.02.011
- Wikipedia, nicotinamide adenosine dinucleotide
- Li DJ, Sun SJ, Fu JT, Ouyang SX, Zhao QJ, Su L, Ji QX, Sun DY, Zhu JH, Zhang GY, Ma JW, Lan XT, Zhao Y, Tong J, Li GQ, Shen FM, Wang P. NAD+-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin. Theranostics. 2021
- Lautrup S, Sinclair DA, Mattson MP, Fang EF. NAD+ in Brain Aging and Neurodegenerative Disorders. Cell Metab. 2019
- Martens CR, Denman BA, Mazzo MR, Armstrong ML, Reisdorph N, McQueen MB, Chonchol M, Seals DR. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018
NAD+ and NADH oxidation/reduction reaction